United Ministries

Website: https://united-ministries.org/
Address: 606 Pendleton St Greenville, SC 29601
Email: info@united-ministries.org
Description: Serves Greenville community members experiencing scarcity of resources. They have several programs, including Place of Hope which provides basic services to the unhoused and case management, emergency financial assistance, adult education, emergency shelter housing, and an economic mobility program. They also offer computer tutoring, computer lab access, mental health counseling, a matched savings program, and incentives for completing goals.

Place of Hope: (864) 232-6463

Emergency Assistance: (864) 336-2661

Adult Education: (864) 335-2604

Emergency Shelter Housing: (864) 271-3424

Striving to Thrive: (864) 605-7696

Youth OUTLOUD

Website: https://www.harriethancockcenter.org/programs/youthoutloud
Address: 1108 Woodrow St, Columbia, SC, 29205
Phone: (803) 771-7713
Description: A group for LGBTQ+ youth in grades 6-12. They aim to promote open discussion and dialogue in a space where experiences can be shared and meaningful connections can be developed. Their vision is to transform safe spaces of support into brave spaces for action. By developing youth leadership and creating opportunities for youth-led initiatives, they aim to empower young leaders to build a strong community for themselves and for others in the Midlands and beyond. Middle school meets on the 2nd and 4th Sundays from 5-7pm. High school meets on the 1st and 3rd Mondays from 6-8pm. Dinner is always provided.

Caregivers of LGBTQ+ Youth

Website: https://www.harriethancockcenter.org/programs/peer-support
Address: 1332 Main Street, Unit #120, Columbia, SC, 29201
Phone: (803) 771-7713
Description: This group is a peer-support group for all caregivers/parents of LGBTQ+ youth. The group aims to provide an environment to learn about the unique experience of caring for someone who identifies as LGBTQ+ and how to better support/affirm them. This group meets during the first Youth OUTLOUD meeting (the 2nd Sunday of the month) at Queer Haven Books from 5-7 PM. No registration required.

Queer x Disabled

Website: https://www.harriethancockcenter.org/programs/peer-support
Address: 1108 Woodrow St, Columbia, SC, 29205
Phone: (803) 771-7713
Description: The group aims to provide information, opportunities, and support for queer disabled folx by giving everyone the chance to make social connections and discuss experiences being both LGBTQIA+ and disabled in the area. We welcome everyone no matter the disability. Open to anyone with visible and non-visible disabilities, mental health and neurodivergent needs, and friends/family of those who may need assistance. This group is held every first Wednesday from 6-8pm. Ages 18+, no registration required.

Queer x BIPOC

Website: https://www.harriethancockcenter.org/programs/peer-support
Location: 1108 Woodrow St, Columbia, SC 29205
Contact: (803) 771-7713
Description: Safe, inclusive space for queer individuals of color to connect, share experiences, and find solidarity. Meets 2nd and 4th Fridays, 7–9 PM. No registration required.

Transfusion

Website: https://www.harriethancockcenter.org/programs/peer-support
Location: 1108 Woodrow Street, Columbia, SC 29205
Contact: (803) 771-7713
Description: Peer-led, non-clinical support group for transgender and gender non-conforming/nonbinary adults. Meets every 3rd Wednesday, 6–8 PM. No registration required.

The Ladies Room SC

Website: https://www.theladiesroomsc.org/home
Location: Upstate, SC
Contact: ebonisims14@gmail.com
Description: The first Black-led, trans-led LGBTQ+ center in Upstate SC serving primarily Black and Brown trans and nonbinary people. Offers skill programs, HRT and name change assistance, STD/STI/HIV services, addiction support, holistic healthcare, emergency housing, food assistance, and more.

Lowcountry Pink Pistols

Website: https://www.facebook.com/groups/lowcountrypinkpistols
Location: Lowcountry areas of Charleston, Berkley, Dorchester, Colleton, Hampton, Jasper, and Beaufort Counties (open to others)
Description: A shooting group honoring diversity and open to all skill levels. They build bridges between the shooting and LGBTQ+ communities, advocating lawful concealed carry for self-defense of sexual minorities.

Lowcountry in Transition

Website: https://www.charlestontranscommunity.org/
Location: Charleston, SC
Contact: lowcountryintransition@gmail.com
Description: A group by and for trans and nonbinary adults supporting each other through community building, support and social events, and resource sharing. Monthly meetings occur 1:00–2:30 PM on the 4th Saturday, with additional online and in-person events.

Uplift Outreach Center

Website: https://upliftoutreachcenter.org/
Location: Spartanburg, SC
Contact: upliftoutreachcenter@gmail.com | (864) 381-7234
Description: Providing a safe space where youth are accepted and partnering with local organizations to provide LGBTQ+ specific resources to our community. They offer support, increase self-advocacy and culturally competent services to decrease suicide and suicidality. They promote tolerance and acceptance while welcoming and encouraging other community members and organizations to participate in their mission of supporting LGBTQ+ youth and their straight allies. Uplift Outreach Center is located behind Fernwood Baptist Church off of Greengate Lane. They are within walking distance of the SPARTA Hillcrest bus route. The Center is now open a few afternoons a week to youth up to age 23. Please call for current open hours.

Pride Myrtle Beach

Website: https://pridemyrtlebeach.org/
Location: Myrtle Beach, SC
Contact: (843) 839-2052
Description: Pride Myrtle Beach is the primary and most active organization advocating for the Myrtle Beach area LGBTQ+ community. Collaborating closely with community organizations, medical providers and local government, they provide easy access to essential services such as medical care, HIV testing and prevention, and educational opportunities. They are also host to a number of cultural events, family spaces, and festivals, including the June Pride Month Picnic and the Myrtle Beach Pride in the Park Festival, drawing thousands of visitors each year. Through their inclusive approach and diverse offerings, Pride Myrtle Beach celebrates and empowers all members of the LGBTQ+ community, ensuring they feel supported and valued year-round.

Alliance For Full Acceptance (AFFA)

Website: https://www.affa-sc.org/
Contact: info@affa-sc.org | (843) 883-0343
Address: 3265 N. Carolina Avenue Suite 202, North Charleston, SC 29405
Description: The Alliance For Full Acceptance (AFFA) is a Charleston-based nonprofit working to achieve, nurture, and defend equality and full acceptance for LGBTQ+ people in South Carolina. AFFA builds partnerships and advocates for awareness, protections, and equality. AFFA Action is its 501(c)(4) sibling focused on legislative advocacy and political action.

Charleston Pride

Website: https://www.charlestonpride.org/
Contact: info@charlestonpride.org
Description: Charleston Pride's mission is to promote LGBTQ visibility through education, heritage celebration, advocacy, and community-wide events like the Charleston Pride Parade and Festival.

Harriet Hancock LGBTQ Center

Website: http://harriethancockcenter.org/
Address: 1108 Woodrow Street, Columbia, SC, 29205
Contact: info@harriethancockcenter.org | (803) 771-7713
Description: The Harriet Hancock LGBT Center is a safe and inclusive home that supports, educates, and empowers the LGBT community, our allies, and our neighbors. They have a vision for South Carolina where all people are accepted and affirmed, regardless of sexual orientation or gender identity, and LGBT people are able to live happy and healthy lives. The Harriet Hancock LGBT Center works to realize this vision in South Carolina, starting in the Greater Columbia community and Midlands region.

MUSC Student Alliance for Equality

Website: https://education.musc.edu/students/spsd/diversity/multicultural-organizations/alliance-for-equality
Contact: reasonee@musc.edu | (843) 792-2146
Description: The MUSC Student Alliance for Equality (formerly the MUSC Gay Straight Alliance) is an organization of students of all orientations and identities at MUSC designed to provide a sense of community, support, and advocacy for anyone whose real or perceived sexual orientation, gender identity, or alliance may put them in an at-risk minority group.

PFLAG: Parents, Families, and Friends of Lesbians and Gays

Website: https://pflag.org/
Address: Multiple SC Locations
Description: PFLAG’s mission is to build on a foundation of loving families united with LGBTQ people and allies who support one another. They aim to educate communities and advocate for LGBTQ equality. Local South Carolina chapters include Charleston, Spartanburg, Anderson, Greenville, Aiken, Rock Hill, and Pawleys Island. Contact information for each chapter is available on the website.

Palmetto Prime

Website: https://chapters.theprimetimersww.com/charlestonsc/
Email: primetimerscharleston@yahoo.com
Description: Palmetto Prime is a social group for older gay or bisexual men, part of the Prime Timers Worldwide network.

PRISM – College of Charleston

Website: http://safezone.cofc.edu/prism/index.php
Address: 66 George Street, Charleston, SC 29424
Email: prismcofc@gmail.com
Description: PRISM is a student-led organization fostering a close-knit, supportive LGBTQ+ and ally community on campus.

MUSC Ryan White HIV/AIDS Clinic

Website: https://muschealth.org/medical-services/infectious-disease/ryan-white-hiv-clinic
Address: 7th Floor, 135 Rutledge Ave, Charleston, SC 29425
Phone: (843) 792-9200
Description: This MUSC clinic serves over 1,300 HIV/AIDS patients through a multidisciplinary team. They offer free, confidential HIV testing, with walk-ins welcome.

The Roper St. Francis Health Services Center

Website: https://www.ryanwhiteofcharleston.org/
Address: 1481 Tobias Gadson Blvd, Charleston, SC, 29407
Phone: (843) 402-3093
Description: The Roper St. Francis Health Services Center (formerly The Ryan White Wellness Center) was founded in 2000 to care for the region’s uninsured patients living with HIV. It empowers patients and the community to take charge of their sexual health while championing overall wellness. It is the only one-stop-shop sexual health center in the tri-county offering more than 20 different onsite services.